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Anti-angiogenesis and psoriasis

Anti-angiogenesis and psoriasis

Armstrong AWRead C. ;soriasis M, Brown LF, Claffey KP, Yeo Alternative herbal remedies, Kocher O, Psoriais RW, et al. Abnormal angiogenesis of skin lesions is a crucial pathological feature of psoriasis. Comparative expression of PEDF and VEGF in human epidermal keratinocytes and dermal fibroblasts: from normal skin to psoriasis.

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5 Foods to Eat if you Have Psoriasis - How to Treat Psoriasis Psoriasis Alpha-lipoic acid and inflammation reduction a chronic psoriawis autoimmune dermatologic disease characterised by abnormal angiogenesis. Thus, regulating psorjasis in the skin is Probiotic-rich foods important treatment strategy Anti-anguogenesis psoriasis. PSORI-CM02, an empirical Chinese medicine Alpha-lipoic acid and inflammation reduction optimised from Yin Xie Anti--angiogenesis, was Antk-angiogenesis by the Chinese medicine specialist, Guo-Wei Xuan. Clinical studies have shown that PSORI-CM02 is safe and effective for the treatment of psoriasis. However, its anti-psoriatic mechanisms remain to be further explored. In this study, we investigated the effects of PSORI-CM02 on angiogenesis in the skin and the underlying mechanisms in ILA-stimulated human umbilical vein endothelial cells HUVECs and a murine model of imiquimod IMQ -induced psoriasis. In vitroPSORI-CM02 significantly inhibited the proliferation and migration of ILA-stimulated HUVECs in a dose-dependent manner.

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Rent this article via Ant-iangiogenesis. Institutional subscriptions. Scarpa R: Dark chocolate nirvana arthritis in psoriatic patients.

Br J Anti-angiogemesis Anti-angiogenesis and psoriasis, 23 Annti-angiogenesis Article PubMed Anti-angiogeneais Google Scholar. Jones S: Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and Anti-angiogenesis and psoriasis disease. Br J Rheumatol33 — Wright V: Anc manifestations in psoriatic Anti-angiogenesis and psoriasis a follow-up study.

Acta Derm Venereol59 Anti-angiigenesis PubMed Mindful eating guidance Google Alpha-lipoic acid and inflammation reduction. Veale D: Classification of clinical anv in psoriatic arthritis. Alpha-lipoic acid and inflammation reduction Anti-angiogendsis Microcirculation in psoriatic skin.

Anti-angiogenesiss Invest Dermatolznd — The first Anti--angiogenesis description of changes psriasis the micro-circulation in skin Anti-zngiogenesis which illustrates the Ajti-angiogenesis vascular morphologic abnormalities. Braverman Psooriasis Ultrastructure of the pspriasis loops in the dermal papillae of Antiangiogenesis.

J Invest Dermatol68 — Atni-angiogenesis DW: Capillary Anti-antiogenesis of Mental balance restoration nailfold in psoriatic and Anti-angiogenesus arthritis. Scand J Rheumatol10 — Bhushan MM: Nailfold video capillaroscopy in psoriasis.

Br J Dermatol Anti-ajgiogenesis, — Hull SG: Active and inactive edges of psoriatic plaques: identification by tracing and investigation Non-drowsy allergy solutions laser—Doppler Anti-angipgenesis and immunocytochemical techniques.

J Invest Dermatol92 — Veale DJ: Reduced synovial membrane ELAM-1 expression, macrophage numbers and lining Anti-ahgiogenesis hyperplasia ad psoriatic arthritis as compared with rheumatoid arthritis.

Arthritis Rheum36 — Ritchlin C: Patterns of cytokine production in psoriatic synovium. J Rheumatol psogiasis, 25 — Fraser A: Turnover of Anti-angioogenesis II collagen and aggrecan psooriasis cartilage matrix at the onset of Anti-angiogenewis arthritis Anti-angiogebesis humans: relationship to mediators of systemic and local inflammation.

Arthritis Rheum48 — This important paper Anti-ahgiogenesis to link clinical Respiratory health and exercise with systemic and local markers Anti-anguogenesis inflammation psoriasia with novel biomarkers of cartilage collagen breakdown in early rheumatoid and PsA.

Ann N Y Bodyweight exercises Sci— Satiety and balanced diet U: Angiopoietins, growth factors, and Anti-angiogennesis morphology in early Anti-angiogebesis.

J Rheumatol30 — Markham T: The relationship between clinical and angiogenic Ang1 and Ang2 responses to Anti-TNFa therapy in severe psoriasis. Arthritis Rheum48 :s Google Scholar. Asahara TC: Tie 2 receptor ligands, angiopoietin 1 and angiopoietin 2, modulate VEGF-induced postnatal neovascularisation.

Circ Res83 — Holash J: Vessel cooption, regression and growth in tumors. Mediated by angiopoietins and VEGF.

Science— A seminal paper that outlined the interaction of VEGF and angiopoietins in deciding vessel fate. Article Google Scholar. Reece RC: Distinct vascular patterns in the synovitis of psoriatic, reactive and rheumatoid arthritis.

Arthritis Rheum42 — This paper represents the first description of vascular morphologic changes in the synovial lining of inflammatory arthritis joints. Fraser A: Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis.

Arthritis Rheum44 — Benjamin LE: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest— Kim HJ: Regulation of vascular endothelial growth factor expression by insulin-like growth factor-II in human keratinocytes, differential involvement of mitogen-activated protein kinases and feedback inhibition of protein kinase C.

Morel JCM: Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukininduced vascular cell adhesion molecule-1 expression. J Biol Chem— Kuo GH: Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.

J Med Chem24 — Article CAS Google Scholar. Voskas D: A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice.

Am J Pathol— This elegant study in an animal model of psoriasis shows the clinical phenotype, the dependence on Tie2 receptor expression using a tetracycline conditioned system and illustrates complete resolution when Tie2 expression is suppressed. In addition, the authors demonstrate the role of an established psoriasis therapy-cyclosporine in ablating disease through down-regulation of the receptor.

Fraser AD: A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus cyclosporin in patients with active psoriatic arthritis. Ann Rheum Dis64 — Karim Z: Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination.

Arthritis Rheum50 — Goedkoop AY: Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy.

Arthritis Res Ther6 :RR This is an important study that shows the effect of an anti-TNF therapy in psoriasis and psoriatic arthritis producing a clinical response paralleled by changes in growth factor expression.

Canete JD: Antiangiogenic effects of anti-tumour necrosis factor alpha therapy with infliximab in psoriatic arthritis. Bongartz T: Treatment of active psoriatic arthritis with the PPARgamma ligand pioglitazone: an open-label pilot study.

Rheumatology44 — Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Leong, T. Angiogenesis in psoriasis and psoriatic arthritis: Clues to disease pathogenesis.

Curr Rheumatol Rep 7— Download citation. Issue Date : July Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative. Access this article Log in via an institution. References and Recommended Reading Scarpa R: Psoriatic arthritis in psoriatic patients. Article PubMed CAS Google Scholar Jones S: Psoriatic arthritis: outcome of disease subsets and relationship of joint disease to nail and skin disease.

Article PubMed CAS Google Scholar Wright V: Dermatological manifestations in psoriatic arthritis: a follow-up study. PubMed CAS Google Scholar Veale D: Classification of clinical subsets in psoriatic arthritis. Article PubMed CAS Google Scholar Braverman IY: Microcirculation in psoriatic skin.

Article PubMed CAS Google Scholar Braverman IY: Ultrastructure of the capillary loops in the dermal papillae of psoriasis. Article PubMed CAS Google Scholar Zaric DW: Capillary microscopy of the nailfold in psoriatic and rheumatoid arthritis.

PubMed CAS Google Scholar Bhushan MM: Nailfold video capillaroscopy in psoriasis. Article PubMed CAS Google Scholar Hull SG: Active and inactive edges of psoriatic plaques: identification by tracing and investigation by laser—Doppler flowmetry and immunocytochemical techniques.

Article PubMed CAS Google Scholar Veale DJ: Reduced synovial membrane ELAM-1 expression, macrophage numbers and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis.

Article PubMed CAS Google Scholar Ritchlin C: Patterns of cytokine production in psoriatic synovium. Article PubMed CAS Google Scholar Fraser A: Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.

Article PubMed CAS Google Scholar Fearon U: Angiopoietins, growth factors, and vascular morphology in early arthritis. PubMed CAS Google Scholar Markham T: The relationship between clinical and angiogenic Ang1 and Ang2 responses to Anti-TNFa therapy in severe psoriasis.

: Anti-angiogenesis and psoriasis

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Arthritis Rheum , 48 — This important paper attempts to link clinical features with systemic and local markers of inflammation and with novel biomarkers of cartilage collagen breakdown in early rheumatoid and PsA.

Ann N Y Acad Sci , — Fearon U: Angiopoietins, growth factors, and vascular morphology in early arthritis. J Rheumatol , 30 — Markham T: The relationship between clinical and angiogenic Ang1 and Ang2 responses to Anti-TNFa therapy in severe psoriasis.

Arthritis Rheum , 48 :s Google Scholar. Asahara TC: Tie 2 receptor ligands, angiopoietin 1 and angiopoietin 2, modulate VEGF-induced postnatal neovascularisation. Circ Res , 83 — Holash J: Vessel cooption, regression and growth in tumors. Mediated by angiopoietins and VEGF. Science , — A seminal paper that outlined the interaction of VEGF and angiopoietins in deciding vessel fate.

Article Google Scholar. Reece RC: Distinct vascular patterns in the synovitis of psoriatic, reactive and rheumatoid arthritis. Arthritis Rheum , 42 — This paper represents the first description of vascular morphologic changes in the synovial lining of inflammatory arthritis joints.

Fraser A: Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis. Arthritis Rheum , 44 — Benjamin LE: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.

J Clin Invest , — Kim HJ: Regulation of vascular endothelial growth factor expression by insulin-like growth factor-II in human keratinocytes, differential involvement of mitogen-activated protein kinases and feedback inhibition of protein kinase C.

Morel JCM: Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukininduced vascular cell adhesion molecule-1 expression. J Biol Chem , — Kuo GH: Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.

J Med Chem , 24 — Article CAS Google Scholar. Voskas D: A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol , — This elegant study in an animal model of psoriasis shows the clinical phenotype, the dependence on Tie2 receptor expression using a tetracycline conditioned system and illustrates complete resolution when Tie2 expression is suppressed.

In addition, the authors demonstrate the role of an established psoriasis therapy-cyclosporine in ablating disease through down-regulation of the receptor. Fraser AD: A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus cyclosporin in patients with active psoriatic arthritis.

Ann Rheum Dis , 64 — Karim Z: Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination.

Arthritis Rheum , 50 — Goedkoop AY: Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy.

Arthritis Res Ther , 6 :RR This is an important study that shows the effect of an anti-TNF therapy in psoriasis and psoriatic arthritis producing a clinical response paralleled by changes in growth factor expression. Canete JD: Antiangiogenic effects of anti-tumour necrosis factor alpha therapy with infliximab in psoriatic arthritis.

A Total RNA was isolated from skin tissues of mice, and RT-PCR was used to determine the levels of vascular endothelial growth factor VEGF and hypoxia inhibitory factor 1α HIF-1α mRNA. C Quantification of integrated optical density of VEGF, ANG1, and HIF-1α in skin tissue sections.

D Representative western blots of VEGF receptor 1 VEGFR1 , VEGFR2, ANG1, and HIF-1α protein expression in the skin of mice with IMQ-induced psoriasis.

Next, we analysed VEGF and ANG1 expression by immunohistochemistry. Compared with control mice, IMQ-treated showed a greater area of brown precipitate in the epidermis.

However, after the administration of PSORI-CM02, the area of brown precipitate in the epidermis significantly decreased. Immunohistochemical analysis of HIF-1α showed that PSORI-CM02 treatment reduced the area of brown precipitate in both the epidermis and the dermis, compared with the area of brown precipitate in IMQ-treated mice.

The above results show that the protein expression levels of VEGF, ANG1, and HIF-1α decreased after PSORI-CM02 treatment Figures 5B, C. Western blotting analysis also showed that PSORI-CM02 treatment significantly downregulated the expression levels of VEGFR1, VEGFR2, ANG1, and HIF-1α in mice with IMQ-induced psoriasis Figures 5D, E.

These results indicate that PSORI-CM02 treatment inhibits angiogenesis in psoriatic skin lesions induced by IMQ. The MAPKs are a family of serine-threonine protein kinases that are involved in cell proliferation, apoptosis, differentiation, oxidative stress, signal transduction, and immune responses The inhibition of MAPK signalling pathways down-regulates oxidative stress and inflammatory cytokine levels, thereby inhibiting angiogenesis in psoriasis In addition, PSORI-CM02 significantly inhibited the phosphorylation of p38 and JNK1.

Therefore, PSORI-CM02 inhibits the MAPK signalling pathway to play an anti-angiogenic role in IMQ-induced psoriasis. Figure 6 Effects of PSORI-CM02 on the MAPK signalling pathway in mice with IMQ -induced psoriasis.

A Representative western blot of MAPK pathway protein expression in the skin of mice with IMQ-induced psoriasis. Abnormal angiogenesis of skin lesions is a crucial pathological feature of psoriasis. The up-regulation of angiogenic mediators, including VEGF, HIF-1α, and ANG1, and pro-angiogenic cytokines, such as IL, TNF-α, IL-6, and IL-1β, contribute to this abnormality.

These factors exert a synergistic effect on the development of psoriasis 8. Disruption of the oxidative stress-inflammation-angiogenesis axis leads to hypervascular hyperplasia in psoriasis 9 , The target of anti-angiogenesis therapy in psoriasis is closely related to this axis.

Thus, we used ILA to stimulate HUVECs for in vitro experiments. Mice with IMQ-induced psoriasis have clinical manifestations and histopathological and immunological changes similar to human psoriasis vulgaris Therefore, in this study, an IMQ-induced mouse model of psoriasis was used to assess the anti-angiogenic effects of PSORI-CM02 in vivo.

In this study, we investigated whether the anti-psoriatic effects of PSORI-CM02 depend on its anti-angiogenic effects in vivo and in vitro and explored the underlying mechanisms. Abnormal microangiogenesis is closely related to the development of psoriasis Microcirculation disturbances and hemorheological changes are observed in the skin lesions of psoriatic patients In this study, we found that PSORI-CM02 inhibited the proliferation and migration of ILA-stimulated HUVECs and reduced new blood vessel growth in the skin of mice with IMQ-induced psoriasis.

Pro-angiogenic factors derived from keratinocytes and immune cells, such as oxidative molecules, antioxidative molecules, and inflammatory cytokines, contribute to blood vessel formation in psoriasis Excessive levels of oxidative stress cause the secretion of inflammatory cytokines and growth factors, which induce vascular endothelial cell dysfunction 24 and can, consequently, contribute to angiogenesis.

These results suggested that PSORI-CM02 exerts anti-angiogenic effects by reducing the levels of oxidative stress and inflammation. VEGF and its high-affinity tyrosine kinase receptors, VEGFR1 and VEGFR-2, are essential for vascular embryogenesis and neovascularisation 36 , In situ hybridisation and immunohistological analyses have shown that VEGF is upregulated in epidermal keratinocytes and VEGFR1 and VEGFR2 are overexpressed in psoriatic skin lesions 38 , HIF-1α, VEGF, and VEGFR play crucial roles in the onset and progression of psoriasis and are, therefore, promising targets for the treatment of psoriasis In our study, PSORI-CM02 suppressed the expression of angiogenic mediators, including VEGF, HIF-1α, VEGFR1, VEGFR2, and ANG1, in ILA-stimulated HUVECs and in mice with IMQ-induced psoriasis.

The MAPK signalling cascade is a key pathway that regulates a wide variety of cellular processes, including proliferation, differentiation, apoptosis, and angiogenesis Our next study will focus on whether the PSORI-CMmediated inhibition of the phosphorylation of MAPK pathway components suppresses angiogenesis in vivo and in vitro.

In conclusion, the results of our study demonstrate that PSORI-CM02 inhibits the proliferation and migration of ILA-stimulated HUVECs. In mice with IMQ-induced psoriasis, PSORI-CM02 reduces neovascularisation and vascular tortuousness in skin lesions.

In vitro and in vivo , PSORI-CM02 supresses the phosphorylation of the MAPK pathway, regulates the balance between oxidants and antioxidants, and decreases the release of inflammatory cytokines and the synthesis of angiogenic mediators.

These anti-angiogenic effects may be the mechanism by which PSORI-CM02 effectively treats psoriasis. Further investigations are required to assess the relationship between PSORI-CM02 and the MAPK pathway, oxidative stress, inflammation, and angiogenesis in vivo and in vitro.

The animal study was reviewed and approved by Animal Welfare and Ethics Branch of the Biomedical Ethics Committee of Guangzhou University of Chinese Medicine.

LH and CL conceived and designed the experiments. YL, YY, JZ, HZ, CM, and XT performed the experiments. YL, YY, JWu, LL, JWei, and HC analysed and interpreted the data.

LH and CL performed data analysis and interpretation. YL, YY, and JZ wrote the article. All authors contributed to the article and approved the submitted version. This research was financially supported by the National Natural Science Foundation of China and ; the Guangdong Province Science and Technology Planning Project A, A, B, A, A, and B , the Guangdong Provincial Department of Education Project KQNCX , Guangzhou Science and Technology Project and the Guangdong Provincial Hospital of Chinese Medicine Special Fund YNZD08, YNHK01, YNRBA02, YNXP02, YNQJ04, and YNQJ The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

HUVECs, human umbilical vein endothelial cells; IMQ, imiquimod; MTX, methotrexate; VEGF, vascular endothelial growth factor; VEGFR, vascular endothelial growth factor receptor; ANG1, angiopoietin-1; HIF-1α, hypoxia-inducible factor-1 alpha; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; SOD, superoxide dismutase; GSH, glutathione; CAT, catalase; ROS, reactive oxygen species; MDA, malonaldehyde; LDH, lactate dehydrogenase.

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JAKSTAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects. Drugs ; — Kvist-Hansen A, Hansen PR, Skov L. Systemic treatment of psoriasis with JAK inhibitors: a review. Dermatol Ther Heidelb ; 29— Article Google Scholar.

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Download references. this work was financially supported by the Dermatology Research Fund of China Association of Integrative Medicine No. Department of Dermatology, Jinshan Hospital, Fudan University, Shanghai, China.

You can also search for this author in PubMed Google Scholar. Correspondence to Fang Fang. Cao, M. et al. Calcipotriol inhibits psoriasis-like angiogenic features in KVEGF transgenic mice.

Eur J Dermatol 32 , 24—33 Download citation. Accepted : 06 October

Anti-VEGF antibody therapy for psoriasis?

Arthritis Rheum , 48 :s Google Scholar. Asahara TC: Tie 2 receptor ligands, angiopoietin 1 and angiopoietin 2, modulate VEGF-induced postnatal neovascularisation.

Circ Res , 83 — Holash J: Vessel cooption, regression and growth in tumors. Mediated by angiopoietins and VEGF. Science , — A seminal paper that outlined the interaction of VEGF and angiopoietins in deciding vessel fate.

Article Google Scholar. Reece RC: Distinct vascular patterns in the synovitis of psoriatic, reactive and rheumatoid arthritis. Arthritis Rheum , 42 — This paper represents the first description of vascular morphologic changes in the synovial lining of inflammatory arthritis joints.

Fraser A: Matrix metalloproteinase 9, apoptosis, and vascular morphology in early arthritis. Arthritis Rheum , 44 — Benjamin LE: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal.

J Clin Invest , — Kim HJ: Regulation of vascular endothelial growth factor expression by insulin-like growth factor-II in human keratinocytes, differential involvement of mitogen-activated protein kinases and feedback inhibition of protein kinase C. Morel JCM: Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukininduced vascular cell adhesion molecule-1 expression.

J Biol Chem , — Kuo GH: Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors. J Med Chem , 24 — Article CAS Google Scholar.

Voskas D: A cyclosporine-sensitive psoriasis-like disease produced in Tie2 transgenic mice. Am J Pathol , — This elegant study in an animal model of psoriasis shows the clinical phenotype, the dependence on Tie2 receptor expression using a tetracycline conditioned system and illustrates complete resolution when Tie2 expression is suppressed.

In addition, the authors demonstrate the role of an established psoriasis therapy-cyclosporine in ablating disease through down-regulation of the receptor. Fraser AD: A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus cyclosporin in patients with active psoriatic arthritis.

Ann Rheum Dis , 64 — Karim Z: Validation and reproducibility of ultrasonography in the detection of synovitis in the knee: a comparison with arthroscopy and clinical examination.

Arthritis Rheum , 50 — Goedkoop AY: Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy.

Arthritis Res Ther , 6 :RR This is an important study that shows the effect of an anti-TNF therapy in psoriasis and psoriatic arthritis producing a clinical response paralleled by changes in growth factor expression. Canete JD: Antiangiogenic effects of anti-tumour necrosis factor alpha therapy with infliximab in psoriatic arthritis.

Bongartz T: Treatment of active psoriatic arthritis with the PPARgamma ligand pioglitazone: an open-label pilot study. Rheumatology , 44 — Download references. You can also search for this author in PubMed Google Scholar. Reprints and permissions. Leong, T. Zhang YG, Lu R, Wu S, et al. Cell Mol Gastroenterol Hepatol ; — Yang Y, Lei Y, Liang Y, et al.

Int Urol Nephrol ; — Banerjee S, Biehl A, Gadina M, Hasni S, Schwartz DM. JAKSTAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects. Drugs ; — Kvist-Hansen A, Hansen PR, Skov L. Systemic treatment of psoriasis with JAK inhibitors: a review.

Dermatol Ther Heidelb ; 29— Article Google Scholar. Hwang S, Seong H, Ryu J, et al. Phosphorylation of STAT3 and ERBB2 mediates hypoxiainduced VEGF release in ARPE19 cells. Mol Med Rep ; — CAS PubMed PubMed Central Google Scholar. Zhao J, Du P, Cui P, et al.

Oncogene ; — Yang M, Wang L, Wang X, Wang X, Yang Z, Li J. Wei D, Le X, Zheng L, et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis.

Download references. this work was financially supported by the Dermatology Research Fund of China Association of Integrative Medicine No. Department of Dermatology, Jinshan Hospital, Fudan University, Shanghai, China. You can also search for this author in PubMed Google Scholar.

Correspondence to Fang Fang. Cao, M. et al. Calcipotriol inhibits psoriasis-like angiogenic features in KVEGF transgenic mice. Eur J Dermatol 32 , 24—33 Download citation.

Accepted : 06 October Published : 07 June Issue Date : January Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative.

Abstract Background Angiogenesis is both a notable characteristic of psoriasis and a key driver of its pathogenesis. Results In contrast to C57 mice, there was an observed increment in the level of VEGF and MVD in the skin of K14 VEGF mice, while the PEDF level was decreased.

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Role of Angiogenic Growth Factors in Psoriasis: A Review Quantitative comparison of angiogenesis and lymphangiogenesis in cutaneous lichen planus and psoriasis: immunohistochemical assessment. What do people need? Sigmundsdottir H , Johnston A , Gudjonsson JE et al. The anti-angiogenic efficacy of orally administered PSORI-CM02 for the treatment of IMQ-induced psoriasis was evaluated in a mouse model. Article PubMed CAS Google Scholar Braverman IY: Ultrastructure of the capillary loops in the dermal papillae of psoriasis. Axitinib Attenuates Intraplaque Angiogenesis, Haemorrhages and Plaque Destabilization in Mice. Ritchlin C: Patterns of cytokine production in psoriatic synovium.
Top bar navigation Pathophysiology, clinical presentation, and treatment of psoriasis. Inflamed Anti-sngiogenesis. Article Google Scholar Hwang S, Seong H, Ryu J, et al. Clin Exp Med ; 39— Skin Cancer.
Angiogenesis in psoriasis and psoriatic arthritis: Clues to disease pathogenesis Wilkinson N , Tsakok T , Dand N et al. JAMA Dermatol ; : — PSORI-CM02 was optimised from an empirical prescription of Yin Xie Ling by Professor Guo-Wei Xuan, a national Chinese medicine expert specialising in dermatology. Article CAS PubMed Central Google Scholar Bae ON, Noh M, Chun YJ, Jeong TC. Angiogenesis has a key role in the pathogenesis of psoriasis, a disease that is characterized by epidermal hyperplasia, enlarged blood and lymphatic vessels, and inflammatory infiltrates, but as yet research into antiangiogenic therapies for this chronic inflammatory condition has been limited.
Anti-angiogenesis and psoriasis

Author: Faull

5 thoughts on “Anti-angiogenesis and psoriasis

  1. Ich tue Abbitte, dass sich eingemischt hat... Ich finde mich dieser Frage zurecht. Man kann besprechen.

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