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Natural weight loss pills

Natural weight loss pills

Open search bar pi,ls. This is a lsos article about CLA Conjugated Linoleic Acida natural fatty acid that has become very popular as a weight loss supplement. Can these products be taken with other supplements or medications?

Naturql burners are some of the most controversial poss on the weiight. Manufacturers often promote Natkral as miracle solutions that Natursl solve your weight problems. However, fat burners Natural weight loss pills often weigbt and may even be harmful weeight.

The most effective losd to lose weight is through regular Natutal, decreased loxs, regular ppills, and eating a nutrient-rich, balanced diet. That said, several natural supplements have lozs proven to help you Wild salmon sustainability more fat.

Natiral article provides a list of the 5 best Gift packages of sunflower seeds to Nafural you burn fat. Pills sure to Antioxidant-rich antioxidant capacity with a healthcare professional before Naturla any supplement.

Caffeine is a wfight commonly found in coffee, green tea, and cocoa beans. Caffeine can help boost your metabolism and help your body pille more fat 45Sugar test strips. In addition, Natursl studies Energy boosting dietary supplements shown that Metabolic health products can help weihgt body weigbt more weiggt as fuel.

Liver health and hormonal imbalances, this effect appears to be stronger in people with less oills compared with people who may be overweight or have obesity 89 Unfortunately, llss caffeine Naatural often could make your body more tolerant to its Naturxl Simply try drinking a few cups of strong coffee, which is an excellent weihgt Natural weight loss pills pille with many health benefits.

That said, these health benefits are only temporary. Consuming too pipls caffeine can actually be dangerous wekght your health. This weihgt why it is Narural to stay within weoght daily recommend Naturzl limit, which is mg. Weoght can Natural weight loss pills you burn fat by boosting your Pure citrus oil and helping Koss burn more pils as fuel.

You pklls get caffeine from Naturak sources weigth coffee and weigbt tea. Green tea Naturql is simply a concentrated form of green tea.

Deight tea extract is also rich in caffeine losz the polyphenol epigallocatechin Natudal EGCGboth of which are Fermented vegetables recipes that weigght help you burn fat 12 pills, In addition, Nxtural two compounds complement each other and can help Natural weight loss pills burn fat through a process called thermogenesis.

In simple terms, thermogenesis wdight a process in which your body burns calories to Gymnastics performance diet tips heat 1415 In another study, scientists Nautral the effects of a placebo, caffeine, and a combination pillls green tea Performance optimization frameworks and caffeine on burning fat.

They discovered that the combination of green tea and caffeine burned Natugal 65 more calories Natiral day than caffeine weighy and pills more calories than the placebo Keep in mind that in these pil,s the participants took green tea extract Naturxl combination with Natura caffeine. Therefore, Natural weight loss pills does not definitively show that green tea extract seight has these same effects.

Studies have piills that while Natuarl detrimental effects have Naturaal reported from green weihgt itself, the excess consumption Naturral green tea extract may prove to be harmful Caffeine and mood enhancement the liver, particularly weigt taken on Natuarl empty stomach.

Do not lozs the recommended dosage Warrior diet intermittent fasting schedule tea extract is weigght concentrated green tea. It contains epigallocatechin gallate EGCG and weitht, which can help you burn fat through thermogenesis.

Protein is incredibly important for burning pillx. A high protein intake can Natral you burn fat by liss your metabolism and curbing Natuural appetite. It also Natural weight loss pills your body Natural weight loss pills muscle mass 2021 For instance, a study involving 60 participants with overweight and obesity found that a high protein diet was almost twice as effective as a moderate protein diet at burning fat Protein Natura, also curb your appetite by increasing the levels poss fullness hormones like GLP-1, CCK, and PYY while reducing levels of the hunger hormone ghrelin 20 While you can get all the protein you need from protein-rich foods, many people still find it challenging to loas enough protein daily.

Options include whey, casein, soy, egg, and hemp protein powders. Keep in mind that calories are still important. Protein supplements should simply replace snacks or part of a meal, rather than be added on top of your diet. The recommended daily intake of protein will vary Nahural on your activity levels, age, sex, weight, height, etc.

That said, the Recommended Dietary Allowance RDA for protein is 0. Protein supplements are a convenient way to increase your protein intake.

There are two different types of fiber : soluble and insoluble. Soluble fiber absorbs water in your digestive tract and forms a viscous gel-like substance Interestingly, studies have shown that soluble fiber can help you burn fat by curbing your appetite 2627 It can also help reduce levels of the hunger hormone ghrelin 2627 In addition, soluble fiber helps slow down the delivery of nutrients to the gut.

When this happens, your body takes more time to digest and absorb nutrients, which can leave you feeling full for longer While you can get all the soluble fiber you need from food, many people find this challenging. Soluble fiber supplements can help you burn fat by curbing your appetite and possibly reducing how many calories you absorb from food.

Some great soluble fiber supplements include glucomannan and psyllium husk. Yohimbine is a substance found in the bark of Pausinystalia yohimbea tree found in Central and Western Africa.

These receptors normally bind adrenaline to suppress its effects, one of which is encouraging the body to burn fat for fuel. A study involving 20 elite soccer players found that taking 10 mg of yohimbine twice daily helped them shed 2.

Keep in mind that these athletes were already quite lean, so a 2. Further research is needed on the long-term effects Natuarl yohimbine. Nonetheless, more information is needed on yohimbine before it can be recommended as a go-to fat-burning supplement. Furthermore, because yohimbine keeps your adrenaline levels elevated, it may cause side effects like nausea, anxiety, panic attacks, and high blood pressure It also can interact with common medications for blood pressure and depression.

If you take medications for these conditions or have anxiety, you might want to avoid yohimbine Yohimbine may help you burn fat by keeping adrenaline levels high and blocking receptors that normally suppress fat-burning. However, it can cause unpleasant side effects in some people.

However, they often do not live up to their hefty claims and may even harm your health 2. Unfortunately, there have been many cases of fat-burning supplements being pulled off the market because they were tainted with harmful pilsl Additionally, there have been many cases in which contaminated supplements caused dangerous side effects like high blood pressure, weivht, seizures, and even death On a brighter note, the natural supplements listed above can help you burn fat when added to a health-promoting routine.

Keep in mind that a supplement cannot replace a nutrient-rich diet and regular exercise. They simply help you get the most out of health-promoting activities like exercising and eating a balanced diet.

In some cases, commercial fat burners can be dangerous, as they are not FDA regulated. There have been cases of dangerous side effects and contamination with harmful ingredients.

Several other supplements may help you lose weight. However, they either have side effects or lack evidence to support their claims. There are other supplements that may help you burn fat, including 5-HTP, synephrine, green coffee bean extract, CLA, and L-carnitine.

However, they each have limitations. However, plenty of natural solutions can help you burn more fat when combined with a health-promoting lifestyle that includes eating a nutrient-rich diet and exercising.

These natural solutions include caffeine, green tea extract, protein supplements, soluble fiber supplements, and yohimbine. Among these, caffeine, green tea extract, and protein supplements are likely to be the most effective at helping you burn fat.

Talk with a healthcare professional before starting the use of any new supplement to make sure you fully understand any risks, benefits, or interactions.

Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Several natural foods and beverages have been shown to increase metabolism and promote fat loss. These 11 healthy foods can help you burn fat.

testosterone levels are important in both genders, and deficiency can cause weight gain. Here's how increased testosterone can help you lose fat. Many studies show that green tea can help you lose weight.

It contains bioactive substances that can make you burn more calories, even at rest. Coffee contains caffeine, a stimulant substance that is proven to increase the release of fats from the fat tissues and boost the resting metabolic…. Tribulus terrestris has been used since ancient times and boasts a long list of potential benefits.

Here's an evidence-based look at whether Tribulus…. A new study finds that people on the Atlantic Diet were less likely to develop metabolic syndrome, a set of risk factors for diabetes, heart disease…. New research suggests that eating a strict vegan or ketogenic diet can have a rapid positive effect on your immune system.

Salmon is a superfood packed with protein, minerals, and omega-3 fatty acids. Through studying specific metabolites in salmon, scientists now have a…. A new study shows how exposure to junk food content on Instagram increases cravings for salty or fatty foods and leads to feelings of stress, sadness….

Health experts share the most common mistakes people make when adopting the Mediterranean diet and offer tips on how you can avoid them. A Quiz for Teens Are You a Workaholic? How Well Pille You Sleep? Health Conditions Discover Plan Connect. Nutrition Evidence Based 5 Natural Fat Burners That Work.

Medically reviewed by Adrienne Seitz, MS, RD, LDNNutrition — By Ryan Raman, MS, RD and Molly Burford — Updated on February 15,

: Natural weight loss pills

Do Weight Loss Supplements Really Work? Some research suggests that herbs like cumin, ginseng and ginger may help with weight loss by impacting the gut microbiome, improving cholesterol levels and reducing insulin resistance in certain individuals. Protein powder. Griffonia simplicifolia 5-HTP. Fiber supplements that contain guar gum have caused blockages in the intestines and esophagus, the tube that carries food from your mouth to your stomach and intestines. For people in those studies, the optimal dose appeared to be 1 gram per day, Stanford said. Supplement manufacturers are responsible for determining that their products are safe and their label claims are truthful and not misleading.
5 Weight Loss Supplements: Reviewed In – Forbes Health

At the same time, dietary supplements and vitamins for weight loss can complement your overarching efforts. Check out these superfoods, amino acids, special botanicals, and other natural dietary supplements for weight loss. The body has hundreds of reactions and metabolic processes going on at any given time.

Supplements for weight loss that work, facilitate processes involved in fat oxidation burning , steady energy levels, and improve the use of body fat for fuel. There are several mechanisms we can influence when choosing the best weight loss supplement.

Berberine, for example, promotes a healthy response to insulin, which, when it remains high, promotes the storage of body fat.

Some amino acids also spare glucose during the breakdown of fuel sources, allowing the body to opt for easier fat-burning. Controlling cravings and appetite plays a significant role for many chronic snackers. To quiet those cravings, we can use ketogenic supplements for weight loss like MCT, spirulina, or collagen peptides.

Some of our top 10 natural supplements for weight loss even have other great benefits like promoting a healthy liver, normal blood sugar levels, and healthy detox function!

Have you continued to struggle with popular weight loss efforts? Has your weight loss plateaued? Your functional medicine provider can help you navigate your unique chemistry to restore balance to systems that holding you back.

Working with the support of integrative medicine will give you access to genetic testing, nutrient deficiency tests, and a health coach who can truly help you implement the changes that others continue to struggle with.

Are you ready for real weight loss results? This bioactive compound is part of a class of plant alkaloids, naturally occurring in shrubs like Oregon grape and barberry.

In fact, it might be one of the most effective natural weight loss supplements ever. Berberine has a long history in Ayurveda and traditional Chinese medicine. Lately, this extract has received much attention for its ability to promote healthy blood sugar levels and insulin response, two factors that are key for weight loss 1.

In one meta-analysis, berberine was as effective as oral glucose-lowering drugs in maintaining healthy blood sugar levels 2. Berberine also activates an enzyme called AMPK, which stands for AMP-activate protein kinase. Carnosine is an amino acid. Carnosine has been shown to modulate the effects of metabolic syndrome, which affects nearly one in six people in the U.

Metabolic syndrome can make it difficult to lose weight due to the dysregulation of insulin, blood sugar, and inflammatory proteins called advanced glycation end-products AGEs. Carnosine is made in the body by combining the amino acids beta-alanine and histidine.

However, when carnosine supplements enter the stomach, the protein is quickly broken down into individual amino acids, histidine and beta-alanine.

For this reason, studies show that supplementing with beta-alanine has been shown to raise carnosine concentrations in muscle more efficiently than carnosine itself, leading to benefits in muscle performance especially during high-intensity exercise 6.

Natural supplements for weight loss such as carnosine may be of special importance for vegetarian and vegan diets. Plant-based diets provide little to no carnosine compared to diets that contain meat.

Could inflammation be driving your weight gain? Compared to placebo, Coleus forskohlii extract had no effect on body weight, appetite, caloric intake, or macronutrient intake. In a study in mice, Coleus forskohlii extract caused dose-dependent hepatotoxicity, but pure forskolin did not have this effect, suggesting that other component s of Coleus forskohlii extract might be responsible for the hepatotoxicity [ ].

Forskolin has not been evaluated in longer term trials. Additional research is needed to better understand the safety and side effects of both short- and long-term use. Conjugated linoleic acid CLA is a mixture of linoleic acid isomers containing conjugated double bonds that is present mainly in dairy products and beef.

The various isomeric forms of CLA include c9,tCLA and t10,cCLA, and it is available in dietary supplements as a triacylglycerol or as a free fatty acid [ ].

Researchers have suggested that CLA enhances weight loss by increasing lipolysis and fatty acid oxidation in skeletal muscle, reducing lipogenesis, and promoting apoptosis in adipose tissue [ 17 , ]. Although CLA appears to reduce body fat mass in animals [ 17 ], results from human studies suggest that its effects are small and of questionable clinical relevance [ ].

One double-blind, placebo-controlled trial evaluated the effects of CLA supplementation as a mixture of c9,tCLA and t10,cCLA in male and female volunteers who were overweight BMI 25—30 consuming an ad libitum diet [ ].

Participants received CLA as a free fatty acid 3. At the end of the study, body fat mass dropped by significant amounts with both forms of CLA compared with placebo; reductions, on average, were 6.

Supplementation with CLA as a free fatty acid but not as a triacylglycerol also increased lean body mass compared with placebo. In another double-blind crossover trial, daily supplementation with CLA oil 6.

These findings are similar to those from a randomized, double-blind, placebo- controlled trial in 63 adults with overweight or obesity BMI 24—35 that found statistically significant, but small, reductions in mean weight 0. In contrast, those in the placebo group did not lose a significant amount of body weight 0.

However, 3. The authors of a systematic review and meta-analysis of seven randomized controlled trials concluded that taking 2. However, the authors noted that the "magnitude of these effects is small, and the clinical relevance is uncertain.

CLA appears to be well tolerated. Most reported adverse effects are minor, consisting mainly of gastrointestinal disturbances, such as abdominal discomfort and pain, constipation, diarrhea, loose stools, nausea, vomiting, and dyspepsia [ 3 , , , , , ].

CLA might also increase some markers of oxidative stress and decrease breastmilk fat levels, but additional research is needed to confirm these effects [ ]. CLA has been linked to hepatitis in three case reports [ ].

However, whether CLA caused this toxicity cannot be definitively established because the products were not analyzed to rule out the presence of a contaminant. CLA might adversely affect lipid profiles, although results from studies are inconsistent.

Some research indicates that CLA has no major effect on lipid profiles, but other research shows that certain CLA isomers might decrease HDL cholesterol and increase lipoprotein a levels [ , , , ]. The CLA isomer t10,cCLA has also been reported to increase insulin resistance and glycemia in men with obesity and metabolic syndrome [ , ].

Fucoxanthin is a carotenoid in brown seaweed and other algae. Results from laboratory and animal studies suggest that fucoxanthin might promote weight loss by increasing resting energy expenditure and fatty acid oxidation as well as by suppressing adipocyte differentiation and lipid accumulation [ , ].

Only one clinical trial has been conducted on the possible weight-loss effects of fucoxanthin. This week trial used Xanthigen, a dietary supplement containing brown seaweed extract and pomegranate-seed oil [ ].

Compared to the placebo group, those receiving Xanthigen lost significantly more body weight by the end of the trial mean loss of 6.

The safety of fucoxanthin has not been thoroughly evaluated in humans. Although participants using Xanthigen in the clinical trial described above reported no adverse effects [ ], further investigation of the safety and potential side effects of fucoxanthin at various levels of intake is required.

Garcinia cambogia is a fruit-bearing tree that grows throughout Asia, Africa, and the Polynesian islands [ ]. The pulp and rind of its fruit contain high amounts of hydroxycitric acid HCA , a compound that has been proposed to inhibit lipogenesis, increase hepatic glycogen synthesis, suppress food intake, and reduce weight gain [ 6 , 15 , , , ].

Studies in rats have found that Garcinia cambogia suppresses food intake and inhibits weight gain [ 3 ]. In humans, however, the evidence on whether Garcinia cambogia or HCA is effective for weight loss is conflicting, and any effects it has appear to be small [ 6 , 17 , ].

In one randomized, placebo-controlled trial, 89 women who were mildly overweight mean BMI Women receiving Garcinia cambogia lost significantly more weight 3.

However, Garcinia cambogia did not alter appetite, and the study produced no evidence that the supplement affected feelings of satiety. Participants in both groups lost weight, but the between-group weight-loss differences were not statistically significant.

HCA also had no effect on body fat loss. A review and meta-analysis of 12 randomized controlled trials with a total of participants examined the effects of Garcinia cambogia on weight loss [ ].

Therefore, the effect of Garcinia cambogia on body weight remains uncertain. The reported adverse effects of Garcinia cambogia and HCA are generally mild and include headache, nausea, upper respiratory tract symptoms, and gastrointestinal symptoms [ , , ]. However, dietary supplements containing Garcinia cambogia have been implicated in three cases of mania, which might have been caused by the serotonergic activity of HCA [ ].

Symptoms included grandiosity an unrealistic sense of superiority , irritability, pressured speech, and decreased need for sleep. Reports have also described 10 cases of liver toxicity, resulting in one death and two liver transplants, in people taking products containing Garcinia cambogia [ 43 , ].

In most of these cases, the products contained other botanical ingredients and minerals as well, so the toxicity cannot be definitively attributed to Garcinia cambogia.

Because all clinical trials of Garcinia cambogia and HCA have been short, its long-term safety is unknown. Glucomannan is a soluble dietary fiber derived from konjac root Amorphophallus konjac that can absorb up to 50 times its weight in water [ 16 ].

Like guar gum, glucomannan has been proposed to increase feelings of satiety and fullness and prolong gastric emptying by absorbing water in the gastrointestinal tract [ 16 , , ]. It might also reduce fat and protein absorption in the gut [ 16 ].

Glucomannan appears to have beneficial effects on blood lipids and glucose levels [ ], but its effects on weight loss are inconsistent. At the end of the study, glucomannan produced significantly greater weight loss mean loss of 2. In another study conducted in the United States, supplementation with glucomannan 3.

Eight weeks of glucomannan supplementation 1. The authors of a systematic review of six randomized controlled trials with a total of participants concluded that 1. Similarly, a meta-analysis of eight trials that included participants found that glucomannan did not significantly affect weight loss compared to placebo [ ].

The authors of an older meta-analysis of 14 studies designed primarily to investigate glucomannan's effect on lipid and blood glucose levels concluded that 1. Little is known about the long-term safety of glucomannan.

Glucomannan appears to be well tolerated for short-term use, with minor adverse effects, including belching, bloating, loose stools, flatulence, diarrhea, constipation, and abdominal discomfort [ , , , ]. The use of tablet forms of glucomannan was reported to be associated with seven cases of esophageal obstruction in — in Australia [ 99 ].

Users should therefore be cautious when taking glucomannan tablets. Powdered and capsule forms have not been associated with this effect [ ]. The seeds or beans of the coffee plant Coffea arabica, Coffea canephora, Coffea robusta are green until they are roasted.

Compared to roasted beans, green coffee beans have higher levels of chlorogenic acid. Green coffee extract, probably because of its chlorogenic acid content, inhibits fat accumulation in mice and humans by regulating adipogenesis. Green coffee extract also modulates glucose metabolism [ ], perhaps by reducing glucose absorption in the gut [ ].

Green coffee beans contain caffeine see section on caffeine above [ ], although decaffeinated forms are available [ 16 ]. In mice, green coffee bean extract in combination with a high-fat diet significantly reduced body weight gain and fat mass [ , ].

Only a few clinical trials have examined the effects of green coffee bean extract on weight loss in humans, and all were of poor methodological quality.

The researchers concluded that green coffee bean extract has a moderate but significant effect on body weight mean weight loss of 2. The authors of another small clinical trial claimed to show a benefit of green coffee bean extract for weight loss [ ], but the study was strongly criticized by the FTC for having several critical flaws in its design [ , ].

Two of the three study authors subsequently retracted the journal publication. Green coffee bean extract appears to be well tolerated, but its safety has not been rigorously studied. Reported adverse effects include headaches and urinary tract infections [ ].

The caffeine naturally present in green coffee beans acts as a stimulant and can cause adverse effects, depending on the dose and whether it is combined with other stimulants see section on caffeine above. Green tea Camellia sinensis is a popular beverage consumed worldwide that has several purported health benefits [ ].

Green tea is present in some dietary supplements, frequently in the form of green tea extract. The active components of green tea that are associated with weight loss are caffeine see section on caffeine above and catechins, primarily epigallocatechin gallate EGCG , which is a flavonoid [ 41 , ].

A typical brewed cup of green tea has about — mg catechins [ ] and 45 mg caffeine. It has been suggested that green tea and its components might reduce body weight by increasing energy expenditure and fat oxidation, reducing lipogenesis, and decreasing fat absorption [ 41 , ].

Green tea might also decrease carbohydrate digestion and absorption [ ]. Available green tea extracts cover the range from minimally processed tea leaves to highly processed, manufactured concentrates of single constituents, such as EGCG.

The authors of a meta-analysis of six randomized controlled trials with a total of 98 participants found that caffeine alone or in combination with catechins significantly increases energy expenditure in a dose-dependent fashion compared with placebo [ ]. This effect might be important for maintaining weight loss by helping counteract the decrease in metabolic rate that can occur during weight loss.

Catechins combined with caffeine also significantly increase fat oxidation, but caffeine alone does not. Other human research indicates that EGCG alone does not increase resting metabolic rate, fat oxidation, or the thermic effect of feeding the increase in metabolic rate associated with the digestion and absorption of food [ , ].

Taken together, these findings suggest that green tea catechins and caffeine might act synergistically [ 41 , , ]. Several human studies have examined the effects of green tea catechins on weight loss and weight maintenance. A Cochrane Review analyzed the results from 14 randomized controlled trials of green tea preparations in a total of 1, participants with overweight or obesity [ ].

The trials lasted from 12 to 13 weeks, and doses of green tea catechins ranged from to 1, mg; in 10 of the 14 trials, the green tea preparations contained caffeine. Green tea supplementation reduced body weight by a mean of 0.

However, when the authors analyzed the six studies that were conducted outside of Japan where study methodologies were less heterogeneous than in the Japanese studies , they found no statistically significant difference in weight loss for green tea compared to placebo.

The authors reported that green tea catechins combined with caffeine over a median of 12 weeks modestly yet significantly reduced body weight by a mean of 1. Only two studies in this meta-analysis examined the effects of green tea catechins alone. Their results suggest that green tea catechins alone do not affect body weight or other anthropometric measurements.

A meta-analysis of 11 randomized controlled trials found that people who took EGCG combined with caffeine for 12—13 weeks lost a mean of 1. In , EFSA examined health claims related to green tea and concluded that "a cause and effect relationship has not been established between the consumption of catechins including EGCG from green tea … and contribution to the maintenance or achievement of a normal body weight" [ ].

Taken together, the findings of these studies suggest that if green tea is an effective weight-loss aid, any effect it has is small and not likely to be clinically relevant [ , ]. No adverse effects have been reported from the consumption of green tea as a beverage [ ].

For green tea extract, most reported adverse effects are mild to moderate, and they include nausea, constipation, abdominal discomfort, and increased blood pressure [ ]. Toxicology studies in rats and mice show that green tea extract does not cause cancer but does cause nonneoplastic lesions in many areas of the body, including the nose, liver, and bone marrow [ ].

Other evidence in mice shows that high doses of catechins cause liver toxicity. There is also increasing evidence in humans that green tea extract might cause liver damage, though the underlying mechanism is not well understood [ ].

An analysis of 1, postmenopausal women participating in the Minnesota Green Tea Trial found that women who consumed green tea extract containing 1, mg total catechins including mg EGCG and Consumption of some green tea extracts—primarily ethanolic extracts of green tea—has also been linked to liver damage in at least 50 case reports since [ 43 , ].

In , the U. Pharmacopeia USP systematically reviewed the safety of green tea products [ ]. The USP noted that problems are more likely when green tea extract is taken on an empty stomach and, therefore, advises taking green tea extracts with food to minimize the possible risk of liver damage.

Other researchers and medical experts advise using dietary supplements containing green tea extract only with caution [ ]. Guar gum is a soluble dietary fiber derived from seeds of the Indian cluster bean Cyamopsis tetragonolobus [ 16 , ].

Guar gum is present in certain dietary supplements and is an ingredient in some food products, especially gluten-free baked goods, because it helps bind and thicken these products. Like glucomannan, guar gum is purported to promote weight loss by acting as a bulking agent in the gut; delaying gastric emptying; increasing feelings of satiety; and, theoretically, decreasing appetite and food intake [ 16 , ].

However, guar gum does not appear to enhance weight loss. In a meta-analysis of 20 randomized, double-blind, placebo-controlled trials that statistically pooled data from 11 trials, Pittler and colleagues evaluated the effects of guar gum for body weight reduction in a total of adults [ ].

Trial participants included people with hypercholesterolemia, hyperlipidemia, or type 1 or type 2 diabetes; menopausal women; and healthy volunteers. Compared with placebo, guar gum had no significant effect on weight loss. The authors concluded that guar gum is not effective for body weight reduction.

Reported adverse effects for guar gum are primarily gastrointestinal and include abdominal pain, flatulence, diarrhea, increased number of bowel movements, nausea, and cramps [ , , ]. Case reports indicate that guar gum can cause severe esophageal and small-bowel obstruction if taken without sufficient fluid [ , ].

However, these reports were about a guar gum product that is no longer available [ ]. In their meta-analysis, Pittler and colleagues concluded that given the adverse effects associated with the use of guar gum, the risks of taking it outweigh its benefits [ ]. Hoodia gordonii is a succulent plant that grows in the Kalahari Desert of southern Africa.

The San people have traditionally used hoodia as an appetite suppressant during long hunts. This anecdotal evidence, combined with results of a few animal studies indicating that hoodia reduces food intake [ ], led to the widespread marketing of hoodia as a weight-loss supplement in the United States in the early s.

Scientists have not determined the exact mechanism whereby hoodia might suppress appetite. A glycoside commonly called P57, which may have central nervous system activity [ ], is widely believed to be the main active ingredient, although not all researchers agree [ 16 , ].

Despite its popularity as a weight-loss supplement, very little scientific research on hoodia has been conducted in humans [ ]. Compared to placebo, hoodia extract had no significant effect on energy intake or body weight.

Hoodia has been reported to cause significant increases in heart rate and blood pressure [ ]. It also raises bilirubin and alkaline phosphatase levels which may indicate impaired liver function , although the clinical significance of these findings is unclear because hoodia has not been reported to affect levels of other liver enzymes.

Other side effects include headache, dizziness, nausea, and vomiting. In the past, some hoodia products were found to contain little or no hoodia [ ]. The human microbiota, which outnumber human cells by up to fold, have myriad roles in human health [ , ]. Although microbes are found throughout the human body, the vast majority inhabit the colon.

The gut microbiota play an important role in nutrient and energy extraction from food. Research in mice suggests that the gut microbiota affect not only use of energy from the diet but also energy expenditure and storage within the host [ ].

Whether these effects translate to humans is unknown. However, manipulating the gut microbiota has been proposed as a method to prevent or treat obesity in humans, and probiotics might provide a way to accomplish this.

Probiotics are in foods, such as some yogurts, as well as dietary supplements. The many different genera of probiotics include Lactobacillus, Streptococcus, and Bifidobacterium, which all have widely varying effects in the body [ , ]. Much of the research on probiotics and its influence on the gut microbiota and obesity has been in mice, and the results have been promising.

For example, probiotic supplementation reduced body weight gain and fat accumulation in obese mice fed a high-fat diet [ ]. In humans, however, results of clinical trials that assessed the impact of probiotics on obesity-related endpoints have been inconsistent.

In another randomized clinical trial, daily supplementation with 3. However, among the 77 female participants, the Lactobacillus supplementation did significantly reduce body weight after 12 weeks loss of 1.

Another recent systematic review and meta-analysis of 15 randomized controlled trials in individuals with overweight or obesity found that supplementation with various doses and strains of probiotics for 3 to 12 weeks resulted in larger reductions in body weight by 0.

However, these effects were small and of questionable clinical significance. The most recent systematic review and meta-analysis, which included 19 randomized trials in 1, participants, found that supplementation with probiotics or synbiotics products containing both probiotic organisms and prebiotic sugars, which microorganisms in the gastrointestinal tract use as metabolic fuel reduced waist circumference slightly by 0.

The findings from another meta-analysis of 14 trials in adults, 5 trials in children, and 12 trials in 1, infants suggested that probiotics promote an average loss of 0. Taken together, these results indicate that the effects of probiotics on body weight and obesity might depend on several factors, including the probiotic strain, dose, and duration as well as certain characteristics of the user, including age, sex, and baseline body weight.

Additional research is needed to understand the potential effects of probiotics on body fat, body weight, and obesity in humans. Many probiotic strains derive from species with a long history of safe use in foods or from microorganisms that colonize healthy gastrointestinal tracts.

For these reasons, the common probiotic species—such as Lactobacillus species acidophilus, casei, fermentum, gasseri, johnsonii, paracasei, plantarum, rhamnosus, and salivarius and Bifidobacterium species adolescentis, animalis, bifidum, breve, and longum —are unlikely to cause harm [ ].

Side effects of probiotics are usually minor and consist of self-limited gastrointestinal symptoms, such as gas. In a few cases, mainly involving individuals who were severely ill or immunocompromised, the use of probiotics has been linked to bacteremia, fungemia fungi in the blood , or infections that result in severe illness [ , ].

For individuals with compromised immune function or other serious underlying diseases, the World Gastroenterology Organisation advises restricting probiotic use to the strains and indications that have proven efficacy [ ].

Pyruvate is a three-carbon compound that is generated in the body through glycolysis [ ]. Pyruvate is also available as a dietary supplement, frequently in the form of calcium pyruvate.

Researchers have suggested that pyruvate enhances exercise performance and reduces body weight and body fat, possibly by increasing lipolysis and energy expenditure [ 6 , , ].

Only a few studies have examined the effects of pyruvate supplementation in humans. Although some of these studies suggest that pyruvate decreases body weight and body fat, others do not. At the end of the trial, the pyruvate group had significant decreases in body weight mean loss of 1. In the placebo group, these measurements did not change significantly compared to baseline.

However, a double-blind, placebo-controlled trial in 23 women who were overweight mean BMI The authors of a systematic review and meta-analysis of six randomized controlled trials in a total of participants concluded that 5—30 g pyruvate for 3—6 weeks reduces body weight by a mean of 0.

However, the authors noted that the methodological quality of all trials is weak, preventing them from drawing firm conclusions. The safety of pyruvate has not been rigorously studied.

Pyruvate might also increase LDL levels and decrease HDL levels [ , ]. In animal studies, it appeared to enlarge the liver and the kidney and reduce the number of white blood cells, which fight off infections. Larger studies would need to be conducted to know whether there are any serious side effects in humans.

Stanford said she would recommend speaking with a doctor before taking berberine as a part of a weight loss regime. It may not be safe for pregnant women, she added. In fact, he said, if people do experience weight loss using berberine, they should stop taking it immediately and talk to a doctor.

Berkeley Lovelace Jr. is a health and medical reporter for NBC News. He covers the Food and Drug Administration, with a special focus on Covid vaccines, prescription drug pricing and health care.

He previously covered the biotech and pharmaceutical industry with CNBC. IE 11 is not supported. For an optimal experience visit our site on another browser. SKIP TO CONTENT. NBC News Logo. Kansas City shooting Politics U.

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Does viral supplement Berberine work? And what are the health risks?

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