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Multivitamin pills

Multivitamin pills

Multivitamin pills team defined MVMs as Multivitamin pills products providing all 12 vitamins plus Multifitamin minerals Multivita,in 9 ]. Mixed berry flavour. Examples: Diseases like celiac, ulcerative colitis, or cystic fibrosis. Herbaland Immune Boost - Raspberry Lemon. Blink Smart Security for Every Home. Heart Health.

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Let others know. Share your story. ADD A COMMENT. Mar 22, Written By Hrefna Pálsdóttir. Jan 28, Medically Reviewed By Alan Carter, PharmD. Share this article. Evidence Based This article is based on scientific evidence, written by experts and fact checked by experts. related stories 8 Foods That Beat a Multivitamin.

Do Gummy Vitamins Work? The Benefits and Downsides. According to Nutritionists, These Are the 7 Ingredients Your Multivitamin Should Have. Synthetic vs Natural Nutrients: Does It Matter? Read this next. By Adda Bjarnadottir, MS, RDN Ice.

By Lizzie Streit, MS, RDN, LD. Medically reviewed by Lindsay Slowiczek, PharmD. Medically reviewed by Eloise Theisen, RN, MSN, AGPCNP-BC. By Mary Jane Brown, PhD, RD UK.

Malanga Health Benefits and More. Medically reviewed by Natalie Olsen, R. The rate of death from breast cancer 6. In addition, a study examined the association between daily MV or MVM use and colon cancer mortality over 16 years in , men and women, most of whom were White and middle-age or older [ 23 ].

During the study, 4, died of colon cancer. Some experts have hypothesized that MVM use might reduce the incidence of cardiovascular disease CVD or rates of deaths from this disease, possibly because certain nutrients in these products might reduce blood pressure or affect vascular function.

Both observational studies and clinical trials have examined this possibility. Studies that have examined associations of MVMs with CVD risk include the Physicians Health Study I. The results showed no significant associations between MV or MVM use and risk of major CVD events, including myocardial infarction MI , stroke, and CVD death.

Furthermore, men who reported using MVs or MVMs for 20 years or more had a lower risk of major CVD events, stroke, ischemic heart disease, and cardiac revascularization than men who did not take MVs or MVMs.

Studies of the association between MVM use and CVD outcomes have focused on several outcomes, including cardiovascular events and mortality. For example, a meta-analysis of 16 prospective cohort studies including the study described above and the two below and two RCTs evaluated the association between use of MVMs defined as containing more than three vitamins and minerals and risk of various CVD outcomes, including coronary heart disease and stroke [ 25 ].

The studies included a total of 2,, participants with a mean age of Overall, MVM supplementation was not associated with better cardiovascular outcomes, including lower risk of mortality from CVD and coronary heart disease, or of stroke incidence and mortality. Another study of CVD outcomes in MVM users matched use of MVMs defined as products containing three or more vitamins and one or more minerals and MVs among 8, adults from NHANES III — with mortality data reported through [ 26 ].

After adjustment for potentially confounding variables e. The study measured rates of major CVD events, including MI, stroke, and CVD death [ 27 ].

Neither baseline use nor changes in use of MVMs over time was associated with changes in the long-term risk of major CVD events, MI, stroke, cardiac revascularizations, or death from CVD. RCTs have focused primarily on the link between MVM use and CVD or all-cause mortality outcomes.

One RCT randomized 1, participants age 50 years and older who had had an MI at least 6 weeks earlier to take a daily MVM containing 27 nutrients many in doses higher than recommended amounts for a median of 31 months range 13 to 60 months or a placebo as well as their standard medications.

The study's goal was to determine whether the supplement reduced the risk of additional cardiovascular events or death [ 28 ].

Participants receiving the supplement did not have significantly fewer cardiovascular events, but this finding should be interpreted with caution because many participants did not take the supplement or placebo as directed, and others withdrew from the study early.

A meta-analysis of nine RCTs not including the study described above evaluated the use of MVMs defined as products that included most vitamins and minerals by 22, individuals and a variety of CVD outcomes—including total CVD incidence and mortality, MI incidence and mortality, and stroke incidence and mortality—and all-cause mortality [ 29 ].

MVM use did not alter the risk of any of these outcomes. Several epidemiological studies and small RCTs have suggested associations between higher intakes of antioxidants or zinc and reduced risk of age-related macular degneration AMD , although not consistently [ 30 ].

In the Age-Related Eye Disease Study AREDS , investigators randomized 4, individuals age 55—80 years who had varying degrees of AMD, cataract, or both conditions to receive a placebo or a daily supplement containing high doses of vitamin C mg , vitamin E International Units [IU] , beta-carotene 15 mg , zinc 80 mg , and copper 2 mg [ 30 , 31 ].

Over an average follow-up period of 6. The supplements did not prevent AMD onset or affect cataract risk. A subsequent study, AREDS2, tested whether adding omega-3 fatty acids containing mg eicosapentaenoic acid [EPA] and mg docosahexaenoic acid [DHA] or lutein 10 mg and zeaxanthin 2 mg to the AREDS formula would make it more effective [ 32 ].

This study included 4, participants age 50—85 years who had intermediate AMD in both eyes or intermediate AMD in one eye and advanced AMD in the other eye. Adding omega-3 fatty acids, lutein and zeaxanthin, or both to the AREDS formulation did not further reduce the risk of progression to advanced AMD.

However, the study showed that beta-carotene was not a required ingredient; the original AREDS formulation without beta-carotene provided the same protective effect on reducing the risk of advanced AMD as the AREDS2 formulation.

Dietary supplements are commonly taken during pregnancy to increase nutrient intakes, especially of key nutrients such as iron and folic acid. Some experts have hypothesized that MVM use might increase the chance of a healthy birth outcome.

A meta-analysis of 20 RCTs investigated whether supplementation with MVMs whose composition varied by study but that contained multiple nutrients including iron and folic acid by pregnant people led to better birth outcomes than use of supplements containing only iron with or without folic acid or, in one study, a placebo [ 33 ].

The trials included , pregnant people from low- or middle-income countries in Africa and Asia as well as in Mexico where malnutrition and micronutrient deficiencies are not uncommon ; only one of the studies was conducted in a high-income country, the United Kingdom. MVM supplementation did not have a beneficial or harmful effect on risk of stillbirths or of perinatal and neonatal mortality in comparison with iron and folic acid supplementation.

The trial in the United Kingdom that compared an MVM to a placebo found no beneficial or harmful effect of the MVM on preterm births, birth at a smaller size than normal gestational age, or low birth weight.

A similar meta-analysis of 13 RCTs investigated whether use by pregnant adolescents and young adults age 10—19 years of an MVM containing multiple nutrients led to better birth outcomes than supplementation with only iron and folic acid [ 34 ].

The trials included a total of 15, pregnant adolescents and young adults from low- or middle-income countries in Africa and Asia. Several studies have evaluated the link between MVM use and many different health outcomes, including cancer, heart disease, osteoporosis, pulmonary diseases, psychiatric disorders, and mortality.

Most have not found an effect of MVM use on any of the health outcomes measured. One of the largest prospective studies of MVM use was the Women's Health Initiative, which evaluated the health of , postmenopausal women age 50—79 years and their risk factors for cancer, heart disease, and osteoporosis.

A total of When the investigators compared the outcomes of supplement users and nonusers, they found no association between use of these products for a median of 8 years and an increased risk of any common cancer or total cancers, CVD, or total mortality [ 35 ]. Investigators who followed a multiethnic cohort of , men and women age 45—75 years living in Hawaii and California for an average 11 years found similar results [ 36 ].

Other observational data on multiple outcomes come from a cross-sectional analysis of data from participants in the National Health Interview Survey.

This analysis included 4, adults who reported taking an MV or MVM during the previous 12 months and 16, nonusers [ 37 ].

The supplement users reported better overall health than the nonusers, but the results showed no differences in various psychological, physical, or functional health outcomes [ 37 ]. Some evidence from RCTs has focused on the use of MVMs to reduce the risk of various chronic diseases.

In , researchers reviewed 63 published RCTs between and early that evaluated the potential impacts of MVs and MVMs and individual nutrient supplements on health and on the risk of certain medical conditions cancer; age-related sensory loss; and cardiovascular, endocrine, neurologic, musculoskeletal, gastroenterologic, renal, and pulmonary diseases [ 7 ].

An expert panel that reviewed this report and participated in a state-of-the-science conference on the use of MVs and MVMs for chronic disease prevention at the National Institutes of Health in concluded that the evidence was insufficient for them to recommend for or against the use of MVs or MVMs to prevent chronic disease [ 1 ].

The Physicians Health Study II was the longest clinical trial to investigate whether MVMs might help prevent chronic disease. The study randomly assigned 14, male physicians in the United States age 50 and older to take a daily MVM Centrum Silver or placebo for a median of Participants who took the MVM did not have fewer major cardiovascular events, myocardial infarctions, strokes, or cardiovascular-related deaths than nonusers [ 38 ].

The supplement also had no effect on cognitive decline with age [ 40 ]. The COcoa Supplement and Multivitamin Outcomes Study COSMOS was a subsequent clinical trial to investigate whether MVMs might help prevent cancer and CVD in both men and women [ 42 ].

This study randomly assigned 8, men age 60 years and older and 12, women age 65 years and older to take a daily MVM Centrum Silver, with small differences in ingredients and amounts than the supplement used in the Physicians Health Study II , a cocoa extract containing mg of cocoa flavanols, both Centrum Silver and the cocoa extract, or both placebos for a median of 3.

An ancillary study to COSMOS, known as COSMOS-Mind, enrolled 2, of the older COSMOS participants mean age 73 years to investigate whether the cocoa extract, MVM, or both supplements might improve cognition compared with placebo over 3 years of daily use [ 43 ].

Participants completed standardized cognitive tests administered over the telephone at baseline and annually for 3 years. MVM supplementation, with or without the cocoa extract, improved global cognition, a benefit most pronounced in participants with a history of CVD.

The MVM also improved memory and executive function. Similar findings were reported from COSMOS-Web, another ancillary study to COSMOS that included 3, participants mean age 71 years [ 44 ]. In this study, participants who took the MVM had significantly better memory at both 1 year and across 3 years of follow-up, on average, compared with those who took placebo.

These findings suggest that MVM supplementation can help maintain or enhance cognitive function in older adults. Other RCTs have evaluated the effects of MVMs on outcomes in individuals with a range of chronic diseases.

One RCT conducted in Linxian, China, randomized 3, persons age 40—69 years who had precancerous lesions in the esophagus a relatively common condition in this population, which had a low dietary intake of several nutrients to receive a daily MVM containing 14 vitamins and 12 minerals in doses two to three times recommended amounts or a placebo for 6 years [ 45 ].

The supplement did not reduce incidence or mortality rates for esophageal cancer or the rate of mortality from any cause. After the investigators followed participants for up to 20 additional years, when participants were no longer taking the study supplement, the use of the MVMs during the RCT did not result in lower rates of total mortality or mortality from any cause of death examined, including cancer, heart disease, and stroke [ 46 ].

One meta-analysis of 21 RCTs investigated whether daily use of MVs and MVMs products containing three or more nutrients for at least 1 year affected mortality risk [ 47 ].

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On Multivitamin pills Multivitmain Week! Lowest Muktivitamin Grass-Fed Collagen. Win FREE Blood Pressure Monitor. Lowest Pillx Grass-Fed Collagen Win Multivitamin pills Blood Pressure Monitor. Item added to your cart. Home Multivitamins Collection: Multivitamins Multivitamins are one of the foundational supplements for your body. Multivitamins are a blend of vitamins, minerals and support ingredients to give your body what is needs. This is a Multivita,in sheet intended Multivitaminn health professionals. For a general plils, see Multivitamin pills Kale for anti-inflammatory fact sheet. MVMs, in particular, are pillx supplements, currently taken by an estimated Multivitamin pills Multivvitamin all Multivitamin pills in the United States, Multivitamin pills one-quarter of children and adolescents take an MVM or MV [ 23 ]. MVM and MV supplements have no standard or regulatory definition, such as what nutrients they must contain or in what amounts. Therefore, these terms refer to products that have widely varying compositions [ 5 ]. These products go by various names, including multis and multiples, and manufacturers determine the combinations and levels of vitamins, minerals, and other ingredients in them.


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